The mnemonic
Acetone, Acetoacetate, BHB: A-A-B
What each word stands for
- AcetoacetateThe first ketone body made from HMG-CoA
- Beta-hydroxybutyrateMost abundant in blood; not detected by nitroprusside
- AcetoneFormed by spontaneous decarboxylation; exhaled, fruity breath
Why it matters clinically
In diabetic ketoacidosis, nitroprusside tests can underestimate ketosis because beta-hydroxybutyrate is not detected.
Where it stops being reliable
It names the three bodies but not the enzymes; HMG-CoA synthase is the rate-limiting step.
Teaching aid, still awaiting independent review. Confirm facts in a standard source.