The mnemonic
All DNA viruses replicate in the nucleus except Pox
What each word stands for
- DNAReplicate in the host nucleus: herpes, adeno, papilloma, parvo, hepadna
- PoxPoxviruses replicate in the cytoplasm using their own polymerase
Why it matters clinically
Explains why vaccinia and variola carry their own enzymes and why they produce cytoplasmic Guarnieri bodies.
Where it stops being reliable
A rule with one exception; it says nothing about RNA viruses.
Teaching aid, still awaiting independent review. Confirm facts in a standard source.