The mnemonic
Hot in body, mould in cold
What each word stands for
- HotAt 37 degrees C they grow as yeast (tissue form)
- ColdAt 25 degrees C they grow as mould (culture form)
Why it matters clinically
Applies to Histoplasma, Blastomyces, Coccidioides, Sporothrix and Talaromyces.
Where it stops being reliable
Coccidioides forms spherules rather than yeast in tissue.
Teaching aid, still awaiting independent review. Confirm facts in a standard source.