The mnemonic
Reflex, Respire, Rhythm
What each word stands for
- ReflexPatellar reflex lost first
- RespireRespiratory depression next
- RhythmCardiac arrest last
Why it matters clinically
Checking reflexes and respiratory rate before each dose prevents toxicity.
Where it stops being reliable
Gives order of toxicity only. Urine output below 30 mL per hour also needs attention, and the antidote is calcium gluconate.
Teaching aid, still awaiting independent review. Confirm facts in a standard source.