The mnemonic
Protein Out, Albumin Down, Oedema Up, Lipids Up
What each word stands for
- Protein OutHeavy proteinuria
- Albumin DownHypoalbuminaemia
- Oedema UpPeriorbital then generalised oedema
- Lipids UpHyperlipidaemia
Why it matters clinically
Defines the nephrotic tetrad used for diagnosis.
Where it stops being reliable
Does not distinguish minimal change disease from other causes.
Teaching aid, still awaiting independent review. Confirm facts in a standard source.