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PSM · Epidemiology: allocation concealment
Sample itemIn a trial, a recruiter who knows the next allocation in a sequence enrols sicker patients into the new drug arm. Which safeguard was lacking?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Allocation concealment
Allocation concealment hides the upcoming assignment from those enrolling participants, such as through central randomisation or sealed opaque envelopes. Its absence permits selection bias at entry.
Option by option
A. Intention-to-treat analysis
Intention-to-treat deals with analysis after the trial.
B. Allocation concealment (correct)
Correct. Concealment prevents recruiters from steering patients.
C. Placebo control
A placebo does not stop biased enrolment.
D. Double blinding
Blinding acts after allocation, on participants and assessors.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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