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Anatomy · Embryology: urinary system
Sample itemA boy has unilateral renal agenesis on ultrasound and is later found to lack the ipsilateral vas deferens. What explains this association?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Defective mesonephric duct, which gives rise to both the ureteric bud and the vas deferens
The ureteric bud arises from the mesonephric duct and induces the metanephric blastema to form the kidney. The mesonephric duct also gives rise to the vas deferens, epididymis, seminal vesicle and ejaculatory duct in males. Failure of the duct therefore causes renal agenesis together with absence of the vas deferens.
Option by option
A. Defective paramesonephric duct, which gives rise to both the ureteric bud and the vas deferens
The paramesonephric duct regresses in males and does not form the ureteric bud.
B. Defective metanephric blastema, which gives rise to both the nephrons and the vas deferens
The blastema forms nephrons but not the vas deferens, which is a duct derivative.
C. Defective mesonephric duct, which gives rise to both the ureteric bud and the vas deferens (correct)
Correct. The mesonephric duct gives rise to both the ureteric bud and the vas deferens.
D. Defective urogenital sinus, which gives rise to both the ureter and the vas deferens
The urogenital sinus forms the bladder and urethra, not the vas deferens or ureteric bud.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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