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Dentistry · Oral medicine and oral cancer: Plummer-Vinson syndrome
Sample itemA middle-aged woman has iron deficiency anaemia, dysphagia due to an upper oesophageal web and a smooth atrophic tongue. Which oral cancer risk is increased?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Squamous cell carcinoma of the oral cavity and hypopharynx
Plummer-Vinson syndrome combines iron deficiency, post-cricoid web and glossitis, and increases the risk of squamous carcinoma of the oral cavity, pharynx and oesophagus. Iron replacement treats the anaemia and web.
Option by option
A. Osteosarcoma of the jaw
Osteosarcoma is unrelated to iron deficiency.
B. Squamous cell carcinoma of the oral cavity and hypopharynx (correct)
Correct. The syndrome predisposes to squamous cell carcinoma.
C. Ameloblastoma
Ameloblastoma is an odontogenic tumour with no relation to the syndrome.
D. Mucoepidermoid carcinoma
Salivary tumours are not related to iron deficiency.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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