Oral pathology: giant cell lesions: practice question

A Dentistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Dentistry · Oral pathology: giant cell lesions

Sample item

A jaw lesion removed from a 45-year-old woman shows multinucleated giant cells in a vascular stroma. Which blood test is most important before labelling it a central giant cell granuloma?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Serum calcium and parathyroid hormone

Brown tumours of hyperparathyroidism are histologically identical to central giant cell granuloma. Calcium and parathyroid hormone must be checked to avoid missing the endocrine disease.

Option by option

  • A. HIV antibody

    HIV testing does not separate giant cell lesions.

  • B. Serum amylase

    Amylase is a salivary or pancreatic marker and is irrelevant to jaw lesions.

  • C. Serum calcium and parathyroid hormone (correct)

    Correct. Hyperparathyroidism must be excluded because the histology is the same.

  • D. Serum IgG4

    IgG4 measurement is for IgG4-related disease and does not help here.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Dentistry question

What is the answer to this Dentistry question?

The best answer is C, Serum calcium and parathyroid hormone. Brown tumours of hyperparathyroidism are histologically identical to central giant cell granuloma.

Why is "HIV antibody" not the answer?

HIV testing does not separate giant cell lesions.

Why is "Serum amylase" not the answer?

Amylase is a salivary or pancreatic marker and is irrelevant to jaw lesions.

Why is "Serum IgG4" not the answer?

IgG4 measurement is for IgG4-related disease and does not help here.

What concept does this question test?

It tests Oral pathology: giant cell lesions in Dentistry. Calcium and parathyroid hormone must be checked to avoid missing the endocrine disease.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Oral pathology: giant cell lesions?

Learn the dental formula, eruption ages and tooth structure once, as tables. Then use the flashcards and the other Dentistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.