Blood physiology: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Physiology · Blood physiology

Sample item

What initiates the intrinsic coagulation pathway in laboratory testing?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Contact activation

The intrinsic pathway is initiated by contact activation involving factor XII on negatively charged surfaces, whereas tissue factor starts the extrinsic pathway.

Option by option

  • A. Fibrinolysis

    Fibrinolysis dissolves clots rather than initiating coagulation.

  • B. Tissue factor

    Tissue factor initiates the extrinsic coagulation pathway.

  • C. Contact activation (correct)

    Correct: contact activation starts the intrinsic pathway.

  • D. Platelet plug only

    Platelet plug formation is primary hemostasis, distinct from pathway initiation.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Physiology questions

Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is C, Contact activation. The intrinsic pathway is initiated by contact activation involving factor XII on negatively charged surfaces, whereas tissue factor starts the extrinsic pathway.

Why is "Fibrinolysis" not the answer?

Fibrinolysis dissolves clots rather than initiating coagulation.

Why is "Tissue factor" not the answer?

Tissue factor initiates the extrinsic coagulation pathway.

Why is "Platelet plug only" not the answer?

Platelet plug formation is primary hemostasis, distinct from pathway initiation.

What concept does this question test?

It tests Blood physiology in Physiology. The correct option holds because: Correct: contact activation starts the intrinsic pathway.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Blood physiology?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.