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OBG · Gynecology
Sample itemWhat is a major risk associated with prolonged unopposed estrogen exposure?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Endometrial hyperplasia
Unopposed estrogen stimulates ongoing endometrial proliferation without progesterone-mediated shedding or stabilization, increasing the risk of hyperplasia and malignancy.
Option by option
A. Otitis media
Otitis media is a middle-ear infection.
B. Cataract
Cataract is an ocular lens opacity.
C. Endometrial hyperplasia (correct)
Correct: unopposed estrogen promotes endometrial hyperplasia.
D. Asthma
Asthma is lower-airway inflammation.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.