Pharmacokinetics: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Pharmacokinetics

Sample item

What can low plasma albumin increase for a highly protein-bound drug?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Free active drug fraction

With less albumin available for binding, a greater proportion of a highly protein-bound drug may remain free, active, and potentially toxic.

Option by option

  • A. Tablet size

    Tablet size is fixed by formulation.

  • B. Free active drug fraction (correct)

    Correct: reduced binding can increase free active drug.

  • C. Drug color

    Drug color is unrelated to protein binding.

  • D. Renal blood flow only

    Albumin level does not directly determine renal blood flow alone.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is B, Free active drug fraction. With less albumin available for binding, a greater proportion of a highly protein-bound drug may remain free, active, and potentially toxic.

Why is "Tablet size" not the answer?

Tablet size is fixed by formulation.

Why is "Drug color" not the answer?

Drug color is unrelated to protein binding.

Why is "Renal blood flow only" not the answer?

Albumin level does not directly determine renal blood flow alone.

What concept does this question test?

It tests Pharmacokinetics in Pharmacology. The correct option holds because: Correct: reduced binding can increase free active drug.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Pharmacokinetics?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.