Carbohydrate metabolism: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Carbohydrate metabolism

Sample item

What is the committed rate-limiting enzyme of glycolysis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Phosphofructokinase-1

Phosphofructokinase-1 is the committed rate-limiting enzyme of glycolysis and responds to cellular energy signals such as ATP and AMP.

Option by option

  • A. Glucose-6-phosphatase

    Glucose-6-phosphatase participates in hepatic glucose release.

  • B. Lactate dehydrogenase

    Lactate dehydrogenase interconverts pyruvate and lactate.

  • C. Phosphofructokinase-1 (correct)

    Correct: PFK-1 controls the committed glycolytic step.

  • D. Hexokinase

    Hexokinase traps glucose but does not provide the committed regulatory step.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is C, Phosphofructokinase-1. Phosphofructokinase-1 is the committed rate-limiting enzyme of glycolysis and responds to cellular energy signals such as ATP and AMP.

Why is "Glucose-6-phosphatase" not the answer?

Glucose-6-phosphatase participates in hepatic glucose release.

Why is "Lactate dehydrogenase" not the answer?

Lactate dehydrogenase interconverts pyruvate and lactate.

Why is "Hexokinase" not the answer?

Hexokinase traps glucose but does not provide the committed regulatory step.

What concept does this question test?

It tests Carbohydrate metabolism in Biochemistry. The correct option holds because: Correct: PFK-1 controls the committed glycolytic step.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Carbohydrate metabolism?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.