Gastrointestinal physiology: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Gastrointestinal physiology

Sample item

What transporter mediates fructose uptake at the intestinal brush border?

ASGLT1BGLUT5CGLUT4DNa-K ATPase

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. GLUT5

Fructose enters enterocytes by facilitated diffusion through GLUT5, unlike glucose and galactose which use sodium-dependent SGLT1 at the apical membrane.

Option by option

A. SGLT1
SGLT1 transports glucose and galactose with sodium.
B. GLUT5 (correct)
Correct: GLUT5 transports fructose across the apical brush border.
C. GLUT4
GLUT4 is insulin-responsive in muscle and adipose tissue.
D. Na-K ATPase
Na-K ATPase maintains gradients but does not directly take up fructose.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is B, GLUT5. Fructose enters enterocytes by facilitated diffusion through GLUT5, unlike glucose and galactose which use sodium-dependent SGLT1 at the apical membrane.

Why is "SGLT1" not the answer?

SGLT1 transports glucose and galactose with sodium.

Why is "GLUT4" not the answer?

GLUT4 is insulin-responsive in muscle and adipose tissue.

Why is "Na-K ATPase" not the answer?

Na-K ATPase maintains gradients but does not directly take up fructose.

What concept does this question test?

It tests Gastrointestinal physiology in Physiology. The correct option holds because: Correct: GLUT5 transports fructose across the apical brush border.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gastrointestinal physiology?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.