Acid-base physiology: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Acid-base physiology

Sample item

What is the renal compensation for chronic respiratory acidosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Increase bicarbonate reabsorption

With chronic carbon dioxide retention, kidneys compensate by retaining bicarbonate and increasing acid excretion, partially correcting the fall in extracellular pH.

Option by option

  • A. Lower ammonium production

    Ammonium production rises to support acid excretion.

  • B. Excrete more bicarbonate

    Bicarbonate excretion would worsen acidemia.

  • C. Stop hydrogen secretion

    Hydrogen secretion increases rather than stops.

  • D. Increase bicarbonate reabsorption (correct)

    Correct: renal bicarbonate retention compensates chronic respiratory acidosis.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is D, Increase bicarbonate reabsorption. With chronic carbon dioxide retention, kidneys compensate by retaining bicarbonate and increasing acid excretion, partially correcting the fall in extracellular pH.

Why is "Lower ammonium production" not the answer?

Ammonium production rises to support acid excretion.

Why is "Excrete more bicarbonate" not the answer?

Bicarbonate excretion would worsen acidemia.

Why is "Stop hydrogen secretion" not the answer?

Hydrogen secretion increases rather than stops.

What concept does this question test?

It tests Acid-base physiology in Physiology. The correct option holds because: Correct: renal bicarbonate retention compensates chronic respiratory acidosis.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Acid-base physiology?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.