Drug safety: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Drug safety

Sample item

What patient factor can increase the risk of digoxin toxicity at a usual dose?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Renal impairment

Digoxin is cleared substantially by the kidneys, so reduced renal function can increase drug concentration and toxicity risk unless dose and monitoring are adjusted.

Option by option

  • A. Correct contact lenses

    Contact-lens correction is unrelated to digoxin pharmacokinetics.

  • B. Normal kidney function

    Normal kidney function reduces rather than increases this risk.

  • C. Healthy appetite

    Appetite does not determine renal digoxin clearance.

  • D. Renal impairment (correct)

    Correct: renal impairment can raise digoxin levels and toxicity risk.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, Renal impairment. Digoxin is cleared substantially by the kidneys, so reduced renal function can increase drug concentration and toxicity risk unless dose and monitoring are adjusted.

Why is "Correct contact lenses" not the answer?

Contact-lens correction is unrelated to digoxin pharmacokinetics.

Why is "Normal kidney function" not the answer?

Normal kidney function reduces rather than increases this risk.

Why is "Healthy appetite" not the answer?

Appetite does not determine renal digoxin clearance.

What concept does this question test?

It tests Drug safety in Pharmacology. The correct option holds because: Correct: renal impairment can raise digoxin levels and toxicity risk.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Drug safety?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.