Toxicology: practice question

A Forensic Medicine question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Forensic Medicine · Toxicology

Sample item

Which clinical toxidrome is most characteristic of organophosphate poisoning?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Miosis, salivation, bronchorrhoea, and bradycardia

Organophosphates inhibit acetylcholinesterase, causing excess cholinergic activity with secretions, bronchospasm or bronchorrhoea, miosis, bradycardia, fasciculations, and weakness that can threaten respiration.

Option by option

  • A. Miosis, salivation, bronchorrhoea, and bradycardia (correct)

    Correct: this is the classic cholinergic organophosphate toxidrome.

  • B. Severe constipation with urinary retention only

    Constipation and retention alone do not describe cholinergic excess.

  • C. Isolated hearing loss

    Hearing loss is not the characteristic acute poisoning syndrome.

  • D. Mydriasis with dry flushed skin

    Dry flushed mydriatic features are more consistent with antimuscarinic toxicity.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Forensic Medicine question

What is the answer to this Forensic Medicine question?

The best answer is A, Miosis, salivation, bronchorrhoea, and bradycardia. Organophosphates inhibit acetylcholinesterase, causing excess cholinergic activity with secretions, bronchospasm or bronchorrhoea, miosis, bradycardia, fasciculations, and weakness that can threaten respiration.

Why is "Severe constipation with urinary retention only" not the answer?

Constipation and retention alone do not describe cholinergic excess.

Why is "Isolated hearing loss" not the answer?

Hearing loss is not the characteristic acute poisoning syndrome.

Why is "Mydriasis with dry flushed skin" not the answer?

Dry flushed mydriatic features are more consistent with antimuscarinic toxicity.

What concept does this question test?

It tests Toxicology in Forensic Medicine. The correct option holds because: Correct: this is the classic cholinergic organophosphate toxidrome.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Toxicology?

Learn postmortem changes with their timelines, and toxicology as poison, sign, test and antidote. Then use the flashcards and the other Forensic Medicine questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.