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Physiology · Haemostasis
Sample itemWhat is the main role of platelets in primary haemostasis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Form an initial platelet plug at vascular injury
Platelets adhere to exposed subendothelial structures, activate, and aggregate to create an initial plug; the coagulation cascade subsequently generates fibrin to stabilize this primary haemostatic response.
Option by option
A. Convert fibrinogen directly into fibrin
Thrombin converts fibrinogen to fibrin during secondary haemostasis.
B. Dissolve established clots
Fibrinolysis dissolves clots through plasmin activity.
C. Form an initial platelet plug at vascular injury (correct)
Correct: platelets create the first plug at a damaged vessel.
D. Transport oxygen to tissues
Erythrocytes, not platelets, are the main oxygen carriers.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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