Genetics: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Genetics

Sample item

What is the usual inheritance pattern of cystic fibrosis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

C. Autosomal recessive

Cystic fibrosis is usually autosomal recessive, requiring pathogenic variants in both copies of the CFTR gene for disease expression.

Option by option

  • A. Autosomal dominant

    Autosomal dominant disease requires one pathogenic allele.

  • B. Mitochondrial only

    Mitochondrial inheritance follows maternal transmission.

  • C. Autosomal recessive (correct)

    Correct: two affected CFTR alleles are usually required.

  • D. X-linked dominant

    CF is not classically X-linked.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Biochemistry questions

Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is C, Autosomal recessive. Cystic fibrosis is usually autosomal recessive, requiring pathogenic variants in both copies of the CFTR gene for disease expression.

Why is "Autosomal dominant" not the answer?

Autosomal dominant disease requires one pathogenic allele.

Why is "Mitochondrial only" not the answer?

Mitochondrial inheritance follows maternal transmission.

Why is "X-linked dominant" not the answer?

CF is not classically X-linked.

What concept does this question test?

It tests Genetics in Biochemistry. The correct option holds because: Correct: two affected CFTR alleles are usually required.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Genetics?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.