Opioids: remifentanil: practice question

A Anaesthesia question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anaesthesia · Opioids: remifentanil

Sample item

Which property of remifentanil is most important when planning postoperative analgesia?

AIts analgesic effect ends rapidly after stopping the infusionBIt causes irreversible opioid receptor blockadeCIt is excreted unchanged only by the kidneysDIt provides prolonged analgesia after a single bolus

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Its analgesic effect ends rapidly after stopping the infusion

Remifentanil is metabolized by nonspecific esterases and has an extremely short context-sensitive half-time. Because analgesia dissipates quickly after infusion cessation, a postoperative pain plan is needed before stopping it.

Option by option

A. Its analgesic effect ends rapidly after stopping the infusion (correct)
Correct. Rapid offset means it does not provide ongoing analgesia after the infusion ends.
B. It causes irreversible opioid receptor blockade
Remifentanil is an opioid agonist, not an irreversible antagonist.
C. It is excreted unchanged only by the kidneys
Its metabolism is not dependent solely on renal excretion.
D. It provides prolonged analgesia after a single bolus
A single bolus has a short-lived effect rather than prolonged postoperative analgesia.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this Anaesthesia question

What is the answer to this Anaesthesia question?

The best answer is A, Its analgesic effect ends rapidly after stopping the infusion. Remifentanil is metabolized by nonspecific esterases and has an extremely short context-sensitive half-time.

Why is "It causes irreversible opioid receptor blockade" not the answer?

Remifentanil is an opioid agonist, not an irreversible antagonist.

Why is "It is excreted unchanged only by the kidneys" not the answer?

Its metabolism is not dependent solely on renal excretion.

Why is "It provides prolonged analgesia after a single bolus" not the answer?

A single bolus has a short-lived effect rather than prolonged postoperative analgesia.

What concept does this question test?

It tests Opioids: remifentanil in Anaesthesia. Because analgesia dissipates quickly after infusion cessation, a postoperative pain plan is needed before stopping it.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Opioids: remifentanil?

Make a table of each agent, its key advantage and its main side effect. Then use the flashcards and the other Anaesthesia questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.