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General Surgery · Transplant surgery: rejection
Sample itemA kidney transplant recipient develops rising creatinine and graft tenderness several weeks after transplantation. Which process should be urgently investigated?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Acute allograft rejection
Rising creatinine after kidney transplantation can signal acute allograft rejection, although obstruction, infection, drug toxicity, and volume issues also require assessment. Early transplant-team evaluation is essential.
Option by option
A. Uncomplicated cataract
Cataract does not explain renal biochemical deterioration.
B. Simple tension headache
A tension headache has no relationship to renal graft function.
C. Acute allograft rejection (correct)
Correct. Graft dysfunction in this time frame requires prompt evaluation for rejection.
D. Expected permanent graft recovery
Stable recovery should not produce unexplained rising creatinine and graft tenderness.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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