Immunization: practice question

A Pediatrics question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pediatrics · Immunization

Sample item

Why are live attenuated vaccines generally avoided in children with severe cellular immunodeficiency?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. The weakened organism may cause disseminated infection

Live attenuated vaccines replicate to stimulate immunity and can cause disease in people with severe T-cell or combined immunodeficiency. Vaccine decisions should be individualized with specialist guidance.

Option by option

  • A. The weakened organism may cause disseminated infection (correct)

    Correct. Impaired cellular immunity can permit uncontrolled replication of the attenuated organism.

  • B. They cannot generate any immune response

    Some immune response may occur, but safety is the principal concern.

  • C. They permanently suppress marrow

    They do not permanently suppress bone marrow.

  • D. They always cause bacterial sepsis

    Live viral vaccines do not inherently cause bacterial sepsis.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pediatrics questions

Questions about this Pediatrics question

What is the answer to this Pediatrics question?

The best answer is A, The weakened organism may cause disseminated infection. Live attenuated vaccines replicate to stimulate immunity and can cause disease in people with severe T-cell or combined immunodeficiency.

Why is "They cannot generate any immune response" not the answer?

Some immune response may occur, but safety is the principal concern.

Why is "They permanently suppress marrow" not the answer?

They do not permanently suppress bone marrow.

Why is "They always cause bacterial sepsis" not the answer?

Live viral vaccines do not inherently cause bacterial sepsis.

What concept does this question test?

It tests Immunization in Pediatrics. Vaccine decisions should be individualized with specialist guidance.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Immunization?

Memorise milestones and the vaccine schedule as tables and revise them often. Then use the flashcards and the other Pediatrics questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.