Carbohydrate metabolism: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Carbohydrate metabolism

Sample item

Why can G6PD deficiency cause haemolysis after oxidant stress?

ARed cells cannot generate enough NADPH to maintain glutathioneBRed cells cannot synthesize haemoglobinCGlucose cannot enter red cellsDPlatelets cannot aggregate

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Red cells cannot generate enough NADPH to maintain glutathione

G6PD deficiency lowers NADPH production in red cells, impairing reduced glutathione regeneration and leaving haemoglobin vulnerable to oxidant damage.

Option by option

A. Red cells cannot generate enough NADPH to maintain glutathione (correct)
Correct: low NADPH weakens antioxidant defence.
B. Red cells cannot synthesize haemoglobin
Haemoglobin synthesis uses different pathways.
C. Glucose cannot enter red cells
Glucose transport is usually preserved.
D. Platelets cannot aggregate
Platelet aggregation is unrelated.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is A, Red cells cannot generate enough NADPH to maintain glutathione. G6PD deficiency lowers NADPH production in red cells, impairing reduced glutathione regeneration and leaving haemoglobin vulnerable to oxidant damage.

Why is "Red cells cannot synthesize haemoglobin" not the answer?

Haemoglobin synthesis uses different pathways.

Why is "Glucose cannot enter red cells" not the answer?

Glucose transport is usually preserved.

Why is "Platelets cannot aggregate" not the answer?

Platelet aggregation is unrelated.

What concept does this question test?

It tests Carbohydrate metabolism in Biochemistry. The correct option holds because: Correct: low NADPH weakens antioxidant defence.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Carbohydrate metabolism?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.