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Biochemistry · Amino acids
Sample itemWhich amino acid is the biochemical precursor of nitric oxide in vascular endothelium?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Arginine
Nitric oxide synthase converts arginine to nitric oxide and citrulline; endothelial nitric oxide then promotes vascular smooth-muscle relaxation.
Option by option
A. Histidine
Histidine is converted to histamine.
B. Methionine
Methionine is important for methyl-group donation.
C. Tryptophan
Tryptophan is a precursor of serotonin.
D. Arginine (correct)
Correct: nitric oxide synthase uses arginine as substrate.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.