Renal physiology: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Renal physiology

Sample item

What stimulates renin release from juxtaglomerular cells?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Reduced renal perfusion pressure

Reduced renal perfusion, low macula-densa sodium, and beta-1 stimulation promote renin release to activate the renin-angiotensin system.

Option by option

  • A. Increased atrial stretch

    Atrial stretch promotes natriuretic peptides.

  • B. Reduced renal perfusion pressure (correct)

    Correct: low perfusion signals renin release.

  • C. Raised arterial pressure

    High pressure suppresses renin.

  • D. High sodium delivery to macula densa

    High sodium delivery suppresses renin.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is B, Reduced renal perfusion pressure. Reduced renal perfusion, low macula-densa sodium, and beta-1 stimulation promote renin release to activate the renin-angiotensin system.

Why is "Increased atrial stretch" not the answer?

Atrial stretch promotes natriuretic peptides.

Why is "Raised arterial pressure" not the answer?

High pressure suppresses renin.

Why is "High sodium delivery to macula densa" not the answer?

High sodium delivery suppresses renin.

What concept does this question test?

It tests Renal physiology in Physiology. The correct option holds because: Correct: low perfusion signals renin release.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Renal physiology?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.