Endocrine physiology: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Endocrine physiology

Sample item

What is the main effect of glucagon on liver metabolism?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Increase glycogenolysis and gluconeogenesis

Glucagon signals fasting in the liver, increasing glycogen breakdown and glucose production while favouring fatty-acid oxidation and ketogenesis.

Option by option

  • A. Increase muscle glucose uptake through GLUT4

    GLUT4 is insulin-responsive in muscle and fat.

  • B. Reduce ketone formation

    Glucagon favours rather than suppresses ketogenesis.

  • C. Promote glycogen synthesis

    Insulin promotes glycogen synthesis.

  • D. Increase glycogenolysis and gluconeogenesis (correct)

    Correct: glucagon raises hepatic glucose output.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is D, Increase glycogenolysis and gluconeogenesis. Glucagon signals fasting in the liver, increasing glycogen breakdown and glucose production while favouring fatty-acid oxidation and ketogenesis.

Why is "Increase muscle glucose uptake through GLUT4" not the answer?

GLUT4 is insulin-responsive in muscle and fat.

Why is "Reduce ketone formation" not the answer?

Glucagon favours rather than suppresses ketogenesis.

Why is "Promote glycogen synthesis" not the answer?

Insulin promotes glycogen synthesis.

What concept does this question test?

It tests Endocrine physiology in Physiology. The correct option holds because: Correct: glucagon raises hepatic glucose output.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Endocrine physiology?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.