Glycogen metabolism: glycogenolysis: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Glycogen metabolism: glycogenolysis

Sample item

Which enzyme releases glucose-1-phosphate from the nonreducing ends of glycogen during glycogenolysis?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Glycogen phosphorylase

Glycogen phosphorylase cleaves alpha-1,4 glycosidic bonds at nonreducing glycogen ends by phosphorolysis, generating glucose-1-phosphate. Debranching enzyme is required when it approaches an alpha-1,6 branch point.

Option by option

  • A. Phosphoglucomutase

    Phosphoglucomutase interconverts glucose-1-phosphate and glucose-6-phosphate.

  • B. Glycogen synthase

    Glycogen synthase elongates glycogen during glycogenesis.

  • C. Branching enzyme

    Branching enzyme creates alpha-1,6 linkages during glycogen synthesis.

  • D. Glycogen phosphorylase (correct)

    Correct. Glycogen phosphorylase is the key enzyme that mobilizes glucose-1-phosphate from glycogen.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is D, Glycogen phosphorylase. Glycogen phosphorylase cleaves alpha-1,4 glycosidic bonds at nonreducing glycogen ends by phosphorolysis, generating glucose-1-phosphate.

Why is "Phosphoglucomutase" not the answer?

Phosphoglucomutase interconverts glucose-1-phosphate and glucose-6-phosphate.

Why is "Glycogen synthase" not the answer?

Glycogen synthase elongates glycogen during glycogenesis.

Why is "Branching enzyme" not the answer?

Branching enzyme creates alpha-1,6 linkages during glycogen synthesis.

What concept does this question test?

It tests Glycogen metabolism: glycogenolysis in Biochemistry. Debranching enzyme is required when it approaches an alpha-1,6 branch point.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Glycogen metabolism: glycogenolysis?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.