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Biochemistry · Glycogen metabolism: glycogenolysis
Sample itemWhich enzyme releases glucose-1-phosphate from the nonreducing ends of glycogen during glycogenolysis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Glycogen phosphorylase
Glycogen phosphorylase cleaves alpha-1,4 glycosidic bonds at nonreducing glycogen ends by phosphorolysis, generating glucose-1-phosphate. Debranching enzyme is required when it approaches an alpha-1,6 branch point.
Option by option
A. Phosphoglucomutase
Phosphoglucomutase interconverts glucose-1-phosphate and glucose-6-phosphate.
B. Glycogen synthase
Glycogen synthase elongates glycogen during glycogenesis.
C. Branching enzyme
Branching enzyme creates alpha-1,6 linkages during glycogen synthesis.
D. Glycogen phosphorylase (correct)
Correct. Glycogen phosphorylase is the key enzyme that mobilizes glucose-1-phosphate from glycogen.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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