Gastrointestinal physiology: pancreatic secretion: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Gastrointestinal physiology: pancreatic secretion

Sample item

Which hormone stimulates bicarbonate-rich pancreatic secretion in response to acidic chyme entering the duodenum?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. Secretin

Secretin is released from duodenal S cells in response to acid and stimulates pancreatic and biliary bicarbonate secretion. This neutralizes gastric acid in the duodenum.

Option by option

  • A. Motilin

    Motilin coordinates fasting migrating motor complexes.

  • B. Secretin (correct)

    Correct. Secretin drives bicarbonate secretion.

  • C. Cholecystokinin only

    CCK principally stimulates enzyme-rich pancreatic secretion and gallbladder contraction.

  • D. Gastrin

    Gastrin stimulates gastric acid secretion.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is B, Secretin. Secretin is released from duodenal S cells in response to acid and stimulates pancreatic and biliary bicarbonate secretion.

Why is "Motilin" not the answer?

Motilin coordinates fasting migrating motor complexes.

Why is "Cholecystokinin only" not the answer?

CCK principally stimulates enzyme-rich pancreatic secretion and gallbladder contraction.

Why is "Gastrin" not the answer?

Gastrin stimulates gastric acid secretion.

What concept does this question test?

It tests Gastrointestinal physiology: pancreatic secretion in Physiology. This neutralizes gastric acid in the duodenum.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gastrointestinal physiology: pancreatic secretion?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.