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General Surgery · Endocrine surgery: pheochromocytoma
Sample itemBefore adrenalectomy for pheochromocytoma, which preoperative medication sequence is essential?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
C. Alpha blockade before adding beta blockade if needed
Alpha blockade is initiated first to prevent catecholamine-mediated vasoconstriction during tumor manipulation; beta blockade can then control tachyarrhythmia after adequate alpha blockade. Reversing the sequence risks unopposed alpha vasoconstriction.
Option by option
A. No preoperative blood-pressure control
Blood-pressure optimization is essential before surgery.
B. Immediate diuretic only
Diuretics do not address catecholamine surges.
C. Alpha blockade before adding beta blockade if needed (correct)
Correct. Alpha blockade must precede beta blockade.
D. Beta blockade first without alpha blockade
Beta blockade first can cause severe hypertension from unopposed alpha stimulation.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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