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General Surgery · Transplant surgery: immunosuppression
Sample itemWhich complication is increased by long-term immunosuppression after organ transplantation?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Opportunistic infection and malignancy
Immunosuppressive therapy lowers rejection risk but increases susceptibility to opportunistic infection and some malignancies, especially skin cancers and lymphoproliferative disorders. Monitoring balances rejection and toxicity.
Option by option
A. Guaranteed absence of rejection
Rejection can still occur despite immunosuppression.
B. Elimination of cardiovascular risk
Cardiovascular risk often remains elevated.
C. Permanent immunity to all viruses
Immunosuppression does not provide antiviral immunity.
D. Opportunistic infection and malignancy (correct)
Correct. Reduced immune surveillance increases infection and cancer risk.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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