Lipoproteins: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Lipoproteins

Sample item

Which apolipoprotein activates lipoprotein lipase to hydrolyze triglycerides in chylomicrons and VLDL?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Apolipoprotein C-II

Apo C-II activates lipoprotein lipase on capillary endothelium, allowing hydrolysis of triglycerides from chylomicrons and VLDL. Apo E mediates remnant uptake by liver.

Option by option

  • A. Apolipoprotein B-100

    Apo B-100 binds LDL receptors and is in VLDL and LDL.

  • B. Apolipoprotein A-I

    Apo A-I activates LCAT in HDL.

  • C. Apolipoprotein E only

    Apo E helps hepatic remnant recognition rather than directly activating LPL.

  • D. Apolipoprotein C-II (correct)

    Correct. Apo C-II is the essential LPL cofactor.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Biochemistry questions

Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is D, Apolipoprotein C-II. Apo C-II activates lipoprotein lipase on capillary endothelium, allowing hydrolysis of triglycerides from chylomicrons and VLDL.

Why is "Apolipoprotein B-100" not the answer?

Apo B-100 binds LDL receptors and is in VLDL and LDL.

Why is "Apolipoprotein A-I" not the answer?

Apo A-I activates LCAT in HDL.

Why is "Apolipoprotein E only" not the answer?

Apo E helps hepatic remnant recognition rather than directly activating LPL.

What concept does this question test?

It tests Lipoproteins in Biochemistry. Apo E mediates remnant uptake by liver.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Lipoproteins?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.