Genetics: genomic imprinting: practice question

A Biochemistry question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Biochemistry · Genetics: genomic imprinting

Sample item

Which disorder can arise from loss of paternal gene expression on chromosome 15?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Prader-Willi syndrome

Prader-Willi syndrome results from loss of paternally expressed genes in the chromosome 15q11-q13 region. Angelman syndrome results from loss of maternal expression in the same region.

Option by option

  • A. Prader-Willi syndrome (correct)

    Correct. Paternal-expression loss produces Prader-Willi syndrome.

  • B. Klinefelter syndrome

    Klinefelter syndrome is usually 47,XXY.

  • C. Angelman syndrome

    Angelman reflects maternal-expression loss.

  • D. Turner syndrome

    Turner syndrome is monosomy X.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Biochemistry question

What is the answer to this Biochemistry question?

The best answer is A, Prader-Willi syndrome. Prader-Willi syndrome results from loss of paternally expressed genes in the chromosome 15q11-q13 region.

Why is "Klinefelter syndrome" not the answer?

Klinefelter syndrome is usually 47,XXY.

Why is "Angelman syndrome" not the answer?

Angelman reflects maternal-expression loss.

Why is "Turner syndrome" not the answer?

Turner syndrome is monosomy X.

What concept does this question test?

It tests Genetics: genomic imprinting in Biochemistry. Angelman syndrome results from loss of maternal expression in the same region.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Genetics: genomic imprinting?

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.