Anticancer drugs: practice question

A Pharmacology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Pharmacology · Anticancer drugs

Sample item

Why is folinic acid used after high-dose methotrexate?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Rescue normal cells from folate blockade

Folinic acid bypasses dihydrofolate reductase blockade in normal cells after high-dose methotrexate, limiting toxicity while preserving antitumour effect.

Option by option

  • A. Block all marrow recovery

    It supports marrow recovery.

  • B. Increase methotrexate renal toxicity

    It reduces rather than increases toxicity.

  • C. Replace antimicrobial prophylaxis

    It is not antimicrobial therapy.

  • D. Rescue normal cells from folate blockade (correct)

    Correct: leucovorin rescues folate-dependent normal tissue.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Pharmacology questions

Questions about this Pharmacology question

What is the answer to this Pharmacology question?

The best answer is D, Rescue normal cells from folate blockade. Folinic acid bypasses dihydrofolate reductase blockade in normal cells after high-dose methotrexate, limiting toxicity while preserving antitumour effect.

Why is "Block all marrow recovery" not the answer?

It supports marrow recovery.

Why is "Increase methotrexate renal toxicity" not the answer?

It reduces rather than increases toxicity.

Why is "Replace antimicrobial prophylaxis" not the answer?

It is not antimicrobial therapy.

What concept does this question test?

It tests Anticancer drugs in Pharmacology. The correct option holds because: Correct: leucovorin rescues folate-dependent normal tissue.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Anticancer drugs?

Learn drugs as classes, then the exception in each class that an examiner would pick. Then use the flashcards and the other Pharmacology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.