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Forensic Medicine · Identification
Sample itemSkeletal remains are found, and nuclear DNA cannot be obtained, but a maternal relative is available. Which DNA analysis is most suitable for identification?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Mitochondrial DNA sequencing
Mitochondrial DNA is present in many copies per cell, resists degradation and is inherited maternally without recombination. It is therefore suitable for degraded remains and matching to maternal relatives, although it cannot distinguish individuals within the same maternal line.
Option by option
A. Y-chromosome analysis of the maternal aunt
A maternal aunt has no Y chromosome, so Y analysis is not possible.
B. Mitochondrial DNA sequencing (correct)
Correct. Maternal inheritance and high copy number make it suitable.
C. Blood group typing
Blood group typing is non-specific and cannot be done on old bone.
D. Karyotyping of the bone marrow
Karyotyping needs living dividing cells and is not an identification method for remains.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.