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Anatomy · Breast: clinical anatomy
Sample itemA 50-year-old woman has a firm breast lump with skin dimpling over it. A second woman has diffuse skin thickening with pitting like an orange peel. Which anatomical changes explain the two signs respectively?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Tumour traction on the suspensory ligaments of Cooper; obstruction of dermal lymphatic channels
The suspensory ligaments of Cooper run from the deep fascia to the skin through the breast, so a tumour that shortens them tethers the skin and causes dimpling. Peau d'orange results from carcinomatous blockage of dermal lymphatics, producing oedema with skin held down at the hair follicles. Nipple retraction is due to involvement of the lactiferous ducts.
Option by option
A. Tumour traction on the suspensory ligaments of Cooper; obstruction of dermal lymphatic channels (correct)
Correct. Ligament traction causes dimpling and lymphatic obstruction causes peau d'orange.
B. Contraction of the pectoral fascia; blockage of the axillary vein
Pectoral fascia fixation limits mobility on muscle contraction, and axillary vein blockage causes arm swelling.
C. Obstruction of dermal lymphatic channels; tumour traction on the suspensory ligaments of Cooper
This reverses the mechanisms, and lymphatic obstruction does not produce a localised dimple.
D. Infiltration of the lactiferous ducts; venous congestion of the subareolar plexus
Duct infiltration causes nipple retraction, and venous congestion does not cause peau d'orange.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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