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Anatomy · Embryology: face and palate
Sample itemA newborn has a unilateral cleft lip extending into the alveolar ridge, with an intact secondary palate. Failure of fusion of which structures on that side explains the defect?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Maxillary prominence and the medial nasal prominence
The upper lip forms when the maxillary prominence fuses with the medial nasal prominence, which carries the philtrum and intermaxillary segment. Failure of this fusion causes a cleft lip that may extend into the primary palate. Cleft palate is a separate failure of the palatine shelves to fuse.
Option by option
A. Maxillary prominence and the lateral nasal prominence
Failure of the maxillary and lateral nasal prominences gives an oblique facial cleft along the nasolacrimal groove.
B. The two mandibular prominences
Failure of the mandibular prominences gives a rare median cleft of the lower lip and mandible.
C. The two palatine shelves with the nasal septum
Failure of the palatine shelves causes a cleft of the secondary palate and the palate is intact here.
D. Maxillary prominence and the medial nasal prominence (correct)
Correct. Cleft lip is caused by failure of the maxillary and medial nasal prominences to merge.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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