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Microbiology · Mycology: chromoblastomycosis
Sample itemA barefoot agricultural worker has a three-year history of a warty cauliflower-like plaque on the leg. A KOH mount of crusts shows thick-walled brown round cells that divide by internal septation, called copper pennies. What is the diagnosis?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Chromoblastomycosis
Chromoblastomycosis is a chronic subcutaneous mycosis caused by dematiaceous fungi such as Fonsecaea pedrosoi, acquired by traumatic implantation. The tissue form is the sclerotic (Medlar) body, a brown round cell that divides by septation. Itraconazole with cryotherapy or excision is used.
Option by option
A. Rhinosporidiosis
Rhinosporidiosis causes mucosal polyps with large sporangia, not sclerotic bodies.
B. Phaeohyphomycosis
Phaeohyphomycosis shows pigmented septate hyphae in tissue rather than sclerotic bodies.
C. Mycetoma
Mycetoma shows grains and draining sinuses, not copper pennies.
D. Chromoblastomycosis (correct)
Correct. Sclerotic bodies in a verrucous lesion define chromoblastomycosis.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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