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Microbiology · Virology: hepatitis A
Sample itemSeveral students in a hostel develop fever, anorexia and jaundice after a common mess meal, and all recover within weeks. Which serological marker best confirms acute infection in the index student?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. IgM anti-HAV
Hepatitis A is a picornavirus spread by the faecal-oral route and does not produce chronic infection. IgM anti-HAV appears at onset of symptoms and indicates acute infection, whereas IgG persists for life after infection or vaccination.
Option by option
A. IgM anti-HAV (correct)
Correct. IgM anti-HAV indicates current or very recent hepatitis A.
B. IgG anti-HAV
IgG anti-HAV remains positive after past infection or vaccination and does not date the illness.
C. HBsAg
HBsAg indicates hepatitis B, which is not spread through a shared meal.
D. Anti-HCV antibody
Anti-HCV would point to hepatitis C, a blood-borne infection.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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