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Microbiology · Bacteriology: rat-bite fever
Sample itemA laboratory worker bitten by a rat develops fever, a rash on the hands and feet and migratory polyarthritis five days after the healed bite. Blood grows, on serum-enriched medium, a pleomorphic Gram-negative bacillus with bulbous swellings and filaments. Which organism is responsible?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
D. Streptobacillus moniliformis
Streptobacillus moniliformis causes Haverhill fever, the form of rat-bite fever with arthritis and rash, and needs enriched medium for growth. Spirillum minus causes the sodoku form, which has a relapsing ulcer and lymphadenitis but little arthritis.
Option by option
A. Spirillum minus
Spirillum minus is a spiral organism, not cultivable, and the sodoku form lacks prominent arthritis.
B. Bartonella henselae
Bartonella henselae causes cat-scratch disease with regional lymphadenitis.
C. Pasteurella multocida
Pasteurella multocida causes rapid cellulitis within 24 hours of a cat or dog bite.
D. Streptobacillus moniliformis (correct)
Correct. Pleomorphic bacilli with bulbous swellings and arthritis after a rat bite indicate S. moniliformis.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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