Gastrointestinal: ileal brake: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Gastrointestinal: ileal brake

Sample item

When unabsorbed fat reaches the distal ileum, gastric emptying and small bowel transit slow down. Which gut peptides mediate this feedback?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Peptide YY and GLP-1

Nutrients in the distal ileum release peptide YY and GLP-1 from L cells. These peptides slow gastric emptying and intestinal transit, and give a sense of satiety, a response called the ileal brake. It allows more time for digestion and absorption of an unabsorbed load.

Option by option

  • A. Peptide YY and GLP-1 (correct)

    Correct. L-cell peptides PYY and GLP-1 mediate the ileal brake.

  • B. Secretin and VIP

    Secretin and VIP stimulate pancreatic bicarbonate and intestinal secretion and do not mediate the ileal brake.

  • C. Motilin and ghrelin

    Motilin and ghrelin stimulate motility and are released in the fasting state.

  • D. Gastrin and histamine

    Gastrin and histamine stimulate gastric acid secretion.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is A, Peptide YY and GLP-1. Nutrients in the distal ileum release peptide YY and GLP-1 from L cells.

Why is "Secretin and VIP" not the answer?

Secretin and VIP stimulate pancreatic bicarbonate and intestinal secretion and do not mediate the ileal brake.

Why is "Motilin and ghrelin" not the answer?

Motilin and ghrelin stimulate motility and are released in the fasting state.

Why is "Gastrin and histamine" not the answer?

Gastrin and histamine stimulate gastric acid secretion.

What concept does this question test?

It tests Gastrointestinal: ileal brake in Physiology. These peptides slow gastric emptying and intestinal transit, and give a sense of satiety, a response called the ileal brake. It allows more time for digestion and absorption of an unabsorbed load.

How hard is this question?

We tag it as a multi-step question: it asks you to combine more than one idea. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Gastrointestinal: ileal brake?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.