Carbohydrate metabolism: SGLT2 inhibition: practice question

The best answer is A, Sodium-glucose cotransporter 2 in the proximal tubule. SGLT2 in the early proximal tubule reabsorbs most filtered glucose.

GLUT2 in the beta cell senses glucose for insulin release, and its inhibition would not produce urinary glucose loss.

SGLT1 in the jejunum absorbs dietary glucose and galactose; inhibition would cause diarrhoea rather than glycosuria.

GLUT4 is the insulin-responsive transporter of muscle and fat, and blocking it would not cause glycosuria.

It tests Carbohydrate metabolism: SGLT2 inhibition in Biochemistry. Gliflozins inhibit it, causing glucosuria and a fall in plasma glucose independent of insulin. The sugar-rich urine predisposes to genital mycotic infections.

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.