General anatomy and histology: Weibel-Palade bodies: practice question

A Anatomy question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anatomy · General anatomy and histology: Weibel-Palade bodies

Sample item

Electron microscopy of an endothelial cell shows rod-shaped membrane-bound granules with parallel tubules. Which substance do they mainly store?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. Von Willebrand factor with P-selectin

Weibel-Palade bodies are endothelial storage granules for von Willebrand factor and P-selectin. They release their contents on endothelial activation to promote platelet adhesion and leukocyte rolling.

Option by option

  • A. Heparin and histamine

    Heparin and histamine are stored in mast cell granules.

  • B. Fibrinogen and thrombin

    Fibrinogen circulates in plasma and is made by the liver; thrombin is formed from prothrombin.

  • C. Prostacyclin and nitric oxide

    Prostacyclin and nitric oxide are synthesised on demand, not stored in granules.

  • D. Von Willebrand factor with P-selectin (correct)

    Correct. Weibel-Palade bodies store von Willebrand factor and P-selectin.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anatomy question

What is the answer to this Anatomy question?

The best answer is D, Von Willebrand factor with P-selectin. Weibel-Palade bodies are endothelial storage granules for von Willebrand factor and P-selectin.

Why is "Heparin and histamine" not the answer?

Heparin and histamine are stored in mast cell granules.

Why is "Fibrinogen and thrombin" not the answer?

Fibrinogen circulates in plasma and is made by the liver; thrombin is formed from prothrombin.

Why is "Prostacyclin and nitric oxide" not the answer?

Prostacyclin and nitric oxide are synthesised on demand, not stored in granules.

What concept does this question test?

It tests General anatomy and histology: Weibel-Palade bodies in Anatomy. They release their contents on endothelial activation to promote platelet adhesion and leukocyte rolling.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study General anatomy and histology: Weibel-Palade bodies?

Learn every nerve by its route, its muscles and what a lesion looks like at the bedside. That one habit answers a large share of questions. Then use the flashcards and the other Anatomy questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.