Embryology: ovotesticular disorder: practice question

A Anatomy question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anatomy · Embryology: ovotesticular disorder

Sample item

A child with ambiguous genitalia has an ovary on one side and an ovotestis on the other. Which karyotype is most common in this condition?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. 46,XX

Ovotesticular disorder of sex development is characterised by both ovarian and testicular tissue in one individual, and the most common karyotype is 46,XX. Some affected individuals carry SRY translocated to an X chromosome or have chimerism or mosaicism.

Option by option

  • A. 47,XXY

    47,XXY is Klinefelter syndrome, with small firm testes and no ovarian tissue.

  • B. 46,XX (correct)

    Correct. Most cases have a 46,XX karyotype.

  • C. 45,X

    45,X is Turner syndrome with streak gonads.

  • D. 46,XY

    A 46,XY karyotype is seen in a minority.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anatomy question

What is the answer to this Anatomy question?

The best answer is B, 46,XX. Ovotesticular disorder of sex development is characterised by both ovarian and testicular tissue in one individual, and the most common karyotype is 46,XX.

Why is "47,XXY" not the answer?

47,XXY is Klinefelter syndrome, with small firm testes and no ovarian tissue.

Why is "45,X" not the answer?

45,X is Turner syndrome with streak gonads.

Why is "46,XY" not the answer?

A 46,XY karyotype is seen in a minority.

What concept does this question test?

It tests Embryology: ovotesticular disorder in Anatomy. Some affected individuals carry SRY translocated to an X chromosome or have chimerism or mosaicism.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Embryology: ovotesticular disorder?

Learn every nerve by its route, its muscles and what a lesion looks like at the bedside. That one habit answers a large share of questions. Then use the flashcards and the other Anatomy questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.