Amino acid metabolism: dopamine beta-hydroxylase and copper: practice question

The best answer is A, Copper. Dopamine beta-hydroxylase is a copper-containing enzyme that also uses ascorbate.

Selenium is a cofactor for glutathione peroxidase and iodothyronine deiodinases.

Zinc is a cofactor of enzymes such as alcohol dehydrogenase and carbonic anhydrase.

Manganese is a cofactor for mitochondrial superoxide dismutase and arginase.

It tests Amino acid metabolism: dopamine beta-hydroxylase and copper in Biochemistry. In Menkes disease the ATP7A copper transporter is defective, so copper cannot reach cuproenzymes, and dopamine is converted poorly to noradrenaline.

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

Build one table of enzyme deficiency, disease, inheritance and key finding, then revise it by spaced recall. Then use the flashcards and the other Biochemistry questions on this site to test what stuck.

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.