Blood and immunity: P2Y12 platelet receptor: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Physiology · Blood and immunity: P2Y12 platelet receptor

Sample item

After coronary stenting, a patient is given aspirin together with a second antiplatelet drug that irreversibly blocks the receptor through which ADP from dense granules amplifies aggregation. Which receptor is blocked?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

D. P2Y12

Clopidogrel and related thienopyridines irreversibly block the platelet P2Y12 ADP receptor, which lowers cAMP-dependent inhibition of activation and weakens GPIIb/IIIa activation. Aspirin acts separately by blocking thromboxane A2 synthesis.

Option by option

  • A. Glycoprotein IIb/IIIa

    GPIIb/IIIa is the fibrinogen receptor and is blocked by abciximab-type drugs rather than the ADP receptor blockers.

  • B. Glycoprotein Ib

    GPIb binds von Willebrand factor for adhesion and is not the ADP receptor.

  • C. Thromboxane A2 receptor

    The thromboxane receptor binds TXA2, whose synthesis aspirin blocks.

  • D. P2Y12 (correct)

    Correct. P2Y12 is the platelet ADP receptor blocked by clopidogrel.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Physiology questions

Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is D, P2Y12. Clopidogrel and related thienopyridines irreversibly block the platelet P2Y12 ADP receptor, which lowers cAMP-dependent inhibition of activation and weakens GPIIb/IIIa activation.

Why is "Glycoprotein IIb/IIIa" not the answer?

GPIIb/IIIa is the fibrinogen receptor and is blocked by abciximab-type drugs rather than the ADP receptor blockers.

Why is "Glycoprotein Ib" not the answer?

GPIb binds von Willebrand factor for adhesion and is not the ADP receptor.

Why is "Thromboxane A2 receptor" not the answer?

The thromboxane receptor binds TXA2, whose synthesis aspirin blocks.

What concept does this question test?

It tests Blood and immunity: P2Y12 platelet receptor in Physiology. Aspirin acts separately by blocking thromboxane A2 synthesis.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Blood and immunity: P2Y12 platelet receptor?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.