Nerve and muscle: chromatolysis: practice question

A Physiology question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Physiology · Nerve and muscle: chromatolysis

Sample item

Two weeks after crush injury to the sciatic nerve, a biopsy of the corresponding spinal motor neurone cell bodies shows swelling, an eccentric nucleus and dispersed Nissl substance. What is this response called?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Chromatolysis

Chromatolysis is the cell body reaction to axonal injury, with swelling, eccentric nucleus and Nissl dispersal as protein synthesis shifts to repair. Wallerian degeneration is the breakdown of the axon segment distal to the lesion.

Option by option

  • A. Chromatolysis (correct)

    Correct. Chromatolysis is the neuronal cell body response to axonal injury.

  • B. Wallerian degeneration

    Wallerian degeneration describes the distal axon, not the cell body.

  • C. Transneuronal atrophy

    Transneuronal atrophy affects neurones that lose input from a degenerated neurone.

  • D. Axonal sprouting

    Axonal sprouting is regrowth from the proximal stump, not the cell body appearance described.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Physiology question

What is the answer to this Physiology question?

The best answer is A, Chromatolysis. Chromatolysis is the cell body reaction to axonal injury, with swelling, eccentric nucleus and Nissl dispersal as protein synthesis shifts to repair.

Why is "Wallerian degeneration" not the answer?

Wallerian degeneration describes the distal axon, not the cell body.

Why is "Transneuronal atrophy" not the answer?

Transneuronal atrophy affects neurones that lose input from a degenerated neurone.

Why is "Axonal sprouting" not the answer?

Axonal sprouting is regrowth from the proximal stump, not the cell body appearance described.

What concept does this question test?

It tests Nerve and muscle: chromatolysis in Physiology. Wallerian degeneration is the breakdown of the axon segment distal to the lesion.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Nerve and muscle: chromatolysis?

For each system, sketch the key graph (pressure–volume loop, oxygen dissociation curve, nephron handling) and explain it aloud. Then use the flashcards and the other Physiology questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.