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Physiology · Nerve and muscle: chromatolysis
Sample itemTwo weeks after crush injury to the sciatic nerve, a biopsy of the corresponding spinal motor neurone cell bodies shows swelling, an eccentric nucleus and dispersed Nissl substance. What is this response called?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
A. Chromatolysis
Chromatolysis is the cell body reaction to axonal injury, with swelling, eccentric nucleus and Nissl dispersal as protein synthesis shifts to repair. Wallerian degeneration is the breakdown of the axon segment distal to the lesion.
Option by option
A. Chromatolysis (correct)
Correct. Chromatolysis is the neuronal cell body response to axonal injury.
B. Wallerian degeneration
Wallerian degeneration describes the distal axon, not the cell body.
C. Transneuronal atrophy
Transneuronal atrophy affects neurones that lose input from a degenerated neurone.
D. Axonal sprouting
Axonal sprouting is regrowth from the proximal stump, not the cell body appearance described.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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