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Physiology · Cardiovascular system: vasovagal syncope
Sample itemA 19-year-old student becomes pale and sweaty at the sight of blood, then faints. Heart rate is 44 per minute and blood pressure 80/45 mmHg. What is the mechanism?
Original practice item, not a recalled exam question. Nothing here is recorded.
The answer and the reasoning
B. Sudden sympathetic withdrawal with vagal surge, causing vasodilatation and bradycardia
In vasovagal (neurally mediated) syncope, emotional or orthostatic triggers cause abrupt withdrawal of sympathetic vasomotor tone and an increase in vagal outflow. Vasodilatation and bradycardia lower cardiac output and cerebral perfusion, and consciousness returns once the patient is supine.
Option by option
A. Primary pump failure from atrioventricular conduction block
Conduction block would not explain the pallor and vasodilatation that follow an emotional trigger.
B. Sudden sympathetic withdrawal with vagal surge, causing vasodilatation and bradycardia (correct)
Correct. Falling vasomotor tone together with vagal slowing of the sinus node produces the faint.
C. Reflex sympathetic surge causing tachyarrhythmia and a fall in stroke volume
This would give tachycardia, whereas this patient is bradycardic and vasodilated.
D. Loss of carotid sinus afferents causing unopposed vasoconstriction
Loss of baroreceptor afferents causes labile hypertension rather than a faint with bradycardia.
Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.
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