Opioids: morphine adverse effects: practice question

A Anaesthesia question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

Try it

Anaesthesia · Opioids: morphine adverse effects

Sample item

Which statement about morphine is correct?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. Its active metabolite morphine-6-glucuronide accumulates in renal failure

Morphine-6-glucuronide is an active metabolite excreted by the kidneys and prolongs opioid effects in renal impairment. Morphine releases histamine and causes miosis.

Option by option

  • A. Its active metabolite morphine-6-glucuronide accumulates in renal failure (correct)

    Correct. M6G accumulates in renal failure.

  • B. It is metabolised by plasma esterases

    Morphine is glucuronidated in the liver, not hydrolysed by esterases.

  • C. It causes mydriasis

    Opioids cause miosis, not mydriasis.

  • D. It does not release histamine

    Morphine does release histamine.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

More Anaesthesia questions

Questions about this Anaesthesia question

What is the answer to this Anaesthesia question?

The best answer is A, Its active metabolite morphine-6-glucuronide accumulates in renal failure. Morphine-6-glucuronide is an active metabolite excreted by the kidneys and prolongs opioid effects in renal impairment.

Why is "It is metabolised by plasma esterases" not the answer?

Morphine is glucuronidated in the liver, not hydrolysed by esterases.

Why is "It causes mydriasis" not the answer?

Opioids cause miosis, not mydriasis.

Why is "It does not release histamine" not the answer?

Morphine does release histamine.

What concept does this question test?

It tests Opioids: morphine adverse effects in Anaesthesia. Morphine releases histamine and causes miosis.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Opioids: morphine adverse effects?

Make a table of each agent, its key advantage and its main side effect. Then use the flashcards and the other Anaesthesia questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.