Muscle relaxants: sugammadex: practice question

A Anaesthesia question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anaesthesia · Muscle relaxants: sugammadex

Sample item

How does sugammadex reverse neuromuscular block?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

B. It encapsulates rocuronium and vecuronium in its cyclodextrin cavity

Sugammadex is a modified gamma-cyclodextrin that forms a tight 1:1 complex with steroidal blockers, particularly rocuronium, removing them from the junction. The complex is excreted in urine.

Option by option

  • A. It inhibits acetylcholinesterase

    Anticholinesterase action belongs to neostigmine.

  • B. It encapsulates rocuronium and vecuronium in its cyclodextrin cavity (correct)

    Correct. It chemically encapsulates the relaxant.

  • C. It stimulates nicotinic receptors

    It does not stimulate receptors.

  • D. It blocks muscarinic receptors

    Muscarinic block is the action of glycopyrrolate.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anaesthesia question

What is the answer to this Anaesthesia question?

The best answer is B, It encapsulates rocuronium and vecuronium in its cyclodextrin cavity. Sugammadex is a modified gamma-cyclodextrin that forms a tight 1:1 complex with steroidal blockers, particularly rocuronium, removing them from the junction.

Why is "It inhibits acetylcholinesterase" not the answer?

Anticholinesterase action belongs to neostigmine.

Why is "It stimulates nicotinic receptors" not the answer?

It does not stimulate receptors.

Why is "It blocks muscarinic receptors" not the answer?

Muscarinic block is the action of glycopyrrolate.

What concept does this question test?

It tests Muscle relaxants: sugammadex in Anaesthesia. The complex is excreted in urine.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Muscle relaxants: sugammadex?

Make a table of each agent, its key advantage and its main side effect. Then use the flashcards and the other Anaesthesia questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.