Muscle relaxants: cisatracurium: practice question

A Anaesthesia question in the style of the NEET PG paper. Answer it first, then read why the right option is right and why each of the others is wrong.

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Anaesthesia · Muscle relaxants: cisatracurium

Sample item

What advantage does cisatracurium have over atracurium?

Original practice item, not a recalled exam question. Nothing here is recorded.

The answer and the reasoning

A. It releases little or no histamine

Cisatracurium is the single R-cis isomer of atracurium, about 3 times more potent, and has minimal histamine release and laudanosine production. It is also eliminated by Hofmann degradation.

Option by option

  • A. It releases little or no histamine (correct)

    Correct. Histamine release is minimal.

  • B. It is metabolised in the liver

    Its elimination is by Hofmann degradation, not hepatic metabolism.

  • C. It is vagolytic

    It does not block vagal receptors.

  • D. It acts faster

    Its onset is slower than that of atracurium.

Source note: Original NextPrep sample item — pending expert review. This item is original practice material awaiting independent expert review, so confirm important facts in a standard textbook.

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Questions about this Anaesthesia question

What is the answer to this Anaesthesia question?

The best answer is A, It releases little or no histamine. Cisatracurium is the single R-cis isomer of atracurium, about 3 times more potent, and has minimal histamine release and laudanosine production.

Why is "It is metabolised in the liver" not the answer?

Its elimination is by Hofmann degradation, not hepatic metabolism.

Why is "It is vagolytic" not the answer?

It does not block vagal receptors.

Why is "It acts faster" not the answer?

Its onset is slower than that of atracurium.

What concept does this question test?

It tests Muscle relaxants: cisatracurium in Anaesthesia. It is also eliminated by Hofmann degradation.

How hard is this question?

We tag it as an application question: it asks you to use a fact on a patient or a finding. The tag is our own editorial judgement, not an official difficulty rating, so read the reason for every option, not only the answer.

How should I study Muscle relaxants: cisatracurium?

Make a table of each agent, its key advantage and its main side effect. Then use the flashcards and the other Anaesthesia questions on this site to test what stuck.

Is this a real NEET PG question?

No. It is an original practice item (editorial status: sample, version 1). NextPrep does not publish recalled or leaked questions, and independent faculty review of this item has not been completed yet, so confirm important facts in a standard textbook.